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Rebuttal to Aung et al, "Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks: Meta-analysis of 10 Trials Involving 77 917 Individuals"


Clemens von Schacky, FAHA, FESC


Recently, "a meta-analysis of all large trials assessing the associations of omega-3 fatty acid supplements with the risk of fatal and nonfatal coronary heart disease and major vascular events" was published in JAMA Cardiology. Only trials with "at least 500 participants and a treatment duration of at least 1 year" were included. The authors concluded that their "meta-analysis demonstrated that omega-3 fatty acids had no significant association with fatal or nonfatal coronary heart disease or any major vascular events. It provides no support for current recommendations for the use of such supplements in people with a history of coronary heart disease." Almost all trials had been part of previous meta-analyses, of which most also had neutral results, whereas some demonstrated a positive effect of omega-3 fatty acids on selected outcomes.



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