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Table 1. Natural resources and effective parts for hair loss treatment.

Part Used In
Botanical Name Alopecia Identified Effective Part Remark
Alpinia officinarum Hance Rhizomes Diarylheptanoid structures 5-alpha reductase inhibitory activity (in vitro) 19
Artocarpus altilis leaves 2-geranyl-2’,3,4,4’- 5-alpha reductase inhibitory activity (in vitro) 20
tetrahydroxydihydrochalcone
Camellia sinensis leaves Polyphenols (Epigallocatechin, 5-alpha reductase inhibitory activity (in vitro and in vivo),
epigallocatechin-3-gallate) increasing the hair growth by up regulating phosphorylated
ERK and Akt and by increasing the BCl-2/Bax ratio
(in vitro) 4,21,22
Carthamus tinctorius L. florets hydroxysafflor yellow A Increasing in the length of cultured hair follicles and
stimulates in the growth of hair with local effects in mice
(in vivo, in vitro), 5-alpha reductase inhibitors (in vitro) 23
Citrullus colocynthis fruits Petroleum ether extract 5-alpha reductase inhibitory activity (in vitro and in vivo) 24,25
Schrad
Cucurbita pepo seed phytostrols 5- alpha reductase inhibitory activity (in vitro and in vivo) 26,27
Curcuma aeruginosa Rhizomes Hexane extract (Sesquiterpenes: germacrone, 5-alpha reductase inhibitory activity (in vitro and in vivo) 28
Roxb. zederone, dehydrocurdione, curcumenol,
zedoarondiol and isocurcumenol)
Cuscuta reflexa Roxb Stems Petroleum ether extract (sterols) 5-alpha reductase inhibitory activity (in vitro) 29
Eclipta alba Hassk Leaves Hydroalcoholic Extract, Petroleum ether 5-alpha reductase inhibitory activity (in vivo) 30
extract
Ganodema lucidum Fr. fruiting body methanol or ethanol extract (triterpenoids 5-alpha reductase inhibitory activity (in vitro) 31
Krast and polysaccharides)
Glycyrrhiza glabra roots petroleum ether extract (phytostrogens) 5-alpha reductase (in vivo) and steroid dehydrogenases
inhibitory activity (invitro) 32
Hibiscus rosa-sinensis Leaves ethanolic and petroleum ether extracts The mechanism has not been discussed, hair growth potential
Linn. were evaluated on the albino rat (in vitro and in vivo) 33
Lygodium japonicum Spores Oleic, linoleic and palmitic acids 5- alpha reductase inhibitory activity (in vitro),
(Thunb.) Sw. anti-androgenic activity using growth of the flank organ in
castrated Syrian hamsters and hair regrowth after shaving in
testosteronetreated C57Black/6CrSlc mice (in vivo)
34
Myrica rubra Sieb. et Zucc bark aqueous ethanol extract (Myricanone, 5-alpha reductase inhibitory activity (in vitro),
Myricanol, Myricetin) anti-androgenic activity using growth of the flank organ in
castrated Syrian hamsters and hair regrowth after shaving in
testosteronetreated C57Black/6CrSlc mice (in vivo) 35
Panax ginseng C.A. Meyer Rhizomes Ginsenoside R0, Procyanidin B-2 5-alpha reductase inhibitory activity (in vivo), modulation of
the expression and translocation of protein kinase
C isozymes in hair epithelial cells 36
Piper nigrum Linn. Fruits and Piperine, cubebin 5-alpha reductase inhibitory activity (in vitro),
leaves and 3,4-dimethoxy-3,4desmethylenedioxy anti-androgenic activity using growth of the flank organ in
cubebin castrated Syrian hamsters and hair regrowth after shaving in
testosterone treated C57Black/6CrSlc mice (in vivo) 37
Phyllanthus emblica L. fruits Ethanol extract 5-alpha reductase inhibitory activity (in vitro), Hair growth
promoting effect using C57BL/6 mice (in vivo) 23
Puerariae Flos flowers 50% ethanolic extract (soyasaponin I and 5-alpha reductase inhibitory activity (in vitro),
kaikasaponin III) anti-androgenic activity using hair growth assay in
testosterone-sensitive male C57Black/6NCrSlc strain mice
(in vivo) 38
Rosmarinus officinalis L. leaves 50% ethanolic extract 5-alpha reductase inhibitory activity (in vitro),
(12-methoxycarnosic acid) anti-androgenic activity using hair growth assay in
testosterone-sensitive male C57Black/6NCrSlc strain mice
and hair growth promoting effect in C3H/He mice that had
their dorsal areas shaved (in vivo) 39
Serenoa repens Fruits Fatty acids, Phytosterols, polyphenols, Blocking of the 5-alpha reductase enzyme and decreasing
flavonoids DHT uptake by hair follicles 40
Sophora flavescence Aiton Roots Alkaloids and flavonoids 5-alpha reductase inhibitory activity, increasing mRNA
levels of growth factors and mediate through the regulation
of growth factors in dermal papilla cells 36
Thujae occidentalis L. Leaves Diterpenes, Flavonoids and Fatty acids, 5-alpha reductase inhibitory activity (in vitro) and an
effective agent in treatment of male pattern hair loss
41
disorder by varying androgen conversion
Ziziphus jujuba Mill. Seeds phenolic compounds, Fatty acids 5-alpha reductase inhibitory activity, Hair growth promoting
activity using the shaved skin of BALB/c mice 42

Asnaashari—Herbal medicines for Androgenic Alopecia ALTERNATIVE THERAPIES, JUL/AUG 2020 VOL. 26 NO. 4 29