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analysis to identify sources of heterogeneity that future   used among the trials related to the definition of  wake
          research on the topic can address.                 promoting, which may have led to heterogeneity. The definitions
             According to some perspectives,  acupuncture therapy   of rehabilitation prognosis rate and GCS variables both had
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          has the function of dredging the meridian, running qi and   relatively low heterogeneity in the selected studies and applied
          blood, and blending yin and yang. Its mechanism is associated   to overall outcomes. In the current meta-analysis, every
          with increasing the blood flow and cerebral vessels, promoting   attempt was made to select outcome measures that were as
          the recovery of nerve cell function and the regeneration of   absolute as possible, reducing heterogeneity.
          axons, and activating the function of the reticular activating   Second, neither the sample size of treatment nor the
          system, which makes the inhibited brain cells reawaken. 48   methodological quality was poor, inhibiting an evaluation of
             Today, patients and medical workers often list   the  effects  of  acupuncture.  For  example,  only
          acupuncture as an option for medical treatment; it is easy to   12 studies 20,22,23,25,26,29,32,33,37,39-42  reported the generation of
          accept because the probability of an adverse reaction is low   random sequences. Due to these methodological flaws in the
          with experienced and skilled practitioners,  but bleeding and   included  studies, the  current review failed to reach  firm
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          hematoma due to lesions in the small vessels can be major   ground on which to base conclusions about the efficacy and
          side  effects  of  acupuncture  therapy.   In  contrast,  some   safety of acupuncture for arousing patients from a coma.
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          pharmacotherapy can have negative consequences for    Third, as different time points were used to measure the
          patients. For example, osmotic agents can improve cerebral   effects of acupuncture, and because the current research
          blood flow following injury but have side effects on global   team chose only the results at the 1-month time point or the
          cerebral blood flow.  In no case has acupuncture been   time point closest to the 1-month point, which may also have
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          associated  with side  effects  in the  context  of  awakening   affected overall outcomes.
          patients from a coma after TBI.                       Fourth, only 1 study  included patients who suffered
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             Some evidence exists for the effectiveness of acupuncture   from diffuse axonal injury (DAI); the current research team
          for some conditions, such as stroke, schizophrenia, insomnia,   included this trial because DAI is one of the most important
          and other conditions 14-16 ; however, more accurate data about   types of TBI.  Nevertheless, it is a source of heterogeneity to
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          its therapeutic efficacy and the side effects on the promoting   include specific disease types in an analysis.
          revival from coma are needed. From an economic perspective,   The current research team believes that stimulation of
          a previously reported meta-analysis  had indicated that   acupoints with acupuncture is  available  for unconscious
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          acupuncture, with or without usual care, has acceptable cost   patients after TBI. However, several important relevant issues
          effectiveness. As the cost of acupuncture is not standardized,   still need to be discussed. The existing studies awakened
          a clear definition of and more studies on the cost effectiveness   unconscious patients using acupuncture therapy on varied
          of acupuncture for arousing patients from a coma are   acupoints, with many auxiliary acupoints, and researchers
          necessary to create a stronger position for acupuncture in   need to determine whether all points or only some specific
          clinical treatment. 52                             points can work. The current research team has also noted
             The current research team used wide inclusion criteria   the fact that the proficiency of the practitioner, the needling
          and performed a sufficient search, without language   manipulation, and the time for needle retention may affect
          restrictions, to find all trials applicable to clinical practice.   the effectiveness of acupuncture.
          Also, the team tried to improve the precision of the risk   Finally, all trials explored the effects of a set of points
          estimates with its strict inclusion criteria. However, all of the   rather than a single acupoint. This could be because most
          included trials were from China only, and none were from   acupuncture therapy needs a combination of different
          other countries, which may provide insufficient data to assess   acupoints as a group; identification of the effects of acupoint
          the overall benefits of acupuncture and may result in a   groups might be more clinically applicable than investigating
          certain degree of selection bias.                  the effectiveness of single acupoints with certain populations
             Two studies evaluated the reporting quality of RCTs    or under certain circumstances. In fact, not enough data are
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          and the quality of reporting in abstracts of RCTs  that had   available to support such an analysis.
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          been published in the 5 leading Chinese medical journals   In consideration of these situations, the current analysis
          that MEDLINE indexes. The results of the quality assessment   further highlights the need for high-quality randomized
          were  not  ideal.  Some  authors  even  think  that  most  trials   studies evaluating the best courses of treatment, the
          published in China overstate the effects of interventions and   comparative effectiveness of different single-acupoint
          are not performed based on methodological criteria for   interventions, needling manipulation, and the time for
          quality.  With the opening of the Chinese Cochrane Center,   needle retention.
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          the current research team expects that Chinese clinical trials
          will pay more attention to quality. 56             CONCLUSION
             It is important, however, to address the weaknesses of the   Despite the differences among the studies, the results for
          current meta-analysis. First, different trials may have had   the GOS, wake-promoting rate and GCS after treatment
          varied defining criteria for the outcome measures considered.   showed considerable convergence with regard to the ability
          The  current  meta-analysis  found  that  different  criteria  were   for acupuncture to awaken patients from a coma. Given the


           56   ALTERNATIVE THERAPIES, JUL/AUG 2020 VOL. 26 NO. 4          Zhang—Acupuncture for Patients in Coma After TBI
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